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Oxidation specific epitopes in asthma: New possibilities for treatment
Christopher D Pascoe1, Jignesh Vaghasiya1, Andrew J Halayko1
1Department of Physiology and Pathophysiology, University of Manitoba, Canada; Biology of Breathing Group, Children's Hospital Research Institute of Manitoba, Canada.
The International Journal of Biochemistry & Cell Biology
|October 18, 2020
Summary
Oxidation specific epitopes (OSEs) are linked to asthma. Targeting OSE clearance may offer a novel therapeutic strategy for asthma by resolving inflammation and tissue damage.
Area of Science:
- Biochemistry
- Immunology
- Pulmonology
Background:
- Oxidative stress is a key factor in asthma pathophysiology.
- Reactive oxygen species cause cellular damage, producing oxidation specific epitopes (OSEs).
- OSEs are elevated in chronic inflammatory diseases and their clearance can resolve inflammation in animal models.
Purpose of the Study:
- To review current understanding of OSEs in asthma.
- To explore OSE clearance mechanisms as a potential therapeutic target for asthma.
Main Methods:
- Literature review of oxidative stress, OSEs, and asthma.
- Analysis of existing research on OSEs in asthma patients and animal models.
Main Results:
- OSEs are present in the lungs of asthma patients during exacerbations.
- The direct link between OSEs and asthma pathobiology is not yet established.
- OSE clearance mechanisms, involving pattern recognition receptors and IgM antibodies, show promise in preclinical models.
Conclusions:
- Targeting OSEs represents a potential novel therapeutic avenue for asthma.
- Further research is needed to confirm the role of OSEs in asthma pathobiology.
- Investigating OSE clearance pathways could lead to new asthma treatments.
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