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Related Concept Videos

Multiple Comparison Tests01:13

Multiple Comparison Tests

4.3K
Multiple comparison test, abbreviated as MCT, is a post hoc analysis generally performed after comparing multiple samples with one or more tests. An MCT will help identify a significantly different sample among multiple samples or a factor among multiple factors.
It would be easy to compare two samples using a significance alpha level of 0.05. In other words, there is only one sample pair to be compared. However, it would be difficult to identify a significantly different sample if the number...
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High-speed Video Microscopy Analysis for First-line Diagnosis of Primary Ciliary Dyskinesia
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CIDP, CMT1B, or CMT1B plus CIDP?

Davide Cardellini1, Giampietro Zanette2, Federica Taioli1,3

  • 1Section of Neurology, Department of Neuroscience, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|October 18, 2020
PubMed
Summary

This case study highlights a patient with Charcot-Marie-Tooth disease type 1B (CMT1B) who developed superimposed chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). High-resolution ultrasound proved crucial in diagnosing this rare dual neuropathy.

Keywords:
Charcot-Marie-Tooth disease (CMT)Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)Myelin protein zero (MPZ)Nerve high-resolution ultrasound (HRUS)

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Area of Science:

  • Neurology
  • Genetics
  • Immunology

Background:

  • Charcot-Marie-Tooth disease type 1 (CMT1) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are distinct peripheral neuropathies.
  • CMT1 results from dysmyelination, while CIDP involves macrophage-mediated demyelination.
  • Atypical CMT1 presentations can mimic CIDP, and CIDP can rarely complicate CMT1.

Observation:

  • A patient with a de novo MPZ gene mutation presented with subclinical CMT1B.
  • This patient subsequently developed symptomatic CIDP, complicating the underlying CMT1B.
  • Peripheral nerve high-resolution ultrasound (HRUS) was instrumental in identifying the coexistence of CMT1B and CIDP.

Findings:

  • The study reports a rare case of superimposed CIDP in a patient with subclinical CMT1B.
  • High-resolution ultrasound (HRUS) effectively differentiated the features of CMT1B and CIDP.
  • The patient showed positive clinical, neurophysiological, and ultrasound responses to immunoglobulin therapy.

Implications:

  • This case underscores the importance of considering superimposed CIDP in CMT1 patients with atypical or worsening symptoms.
  • HRUS is a valuable tool for diagnosing coexisting demyelinating neuropathies.
  • Understanding these complex interactions aids in accurate diagnosis and effective treatment strategies for peripheral neuropathies.