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Critical complications of COVID-19: A descriptive meta-analysis study

Kimia Vakili1, Mobina Fathi1, Aiyoub Pezeshgi2

  • 1Student research committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, 198571743, Tehran, IR Iran.

Reviews in Cardiovascular Medicine
|October 19, 2020
PubMed

Insights

This meta-analysis reveals the high prevalence of fever and cough in COVID-19 patients. Cardiac and renal complications are common following respiratory issues in coronavirus disease 2019.

Area of Science:

  • Infectious Diseases
  • Cardiology
  • Pulmonology
  • Nephrology

Background:

  • Coronavirus disease 2019 (COVID-19) rapidly emerged as a global pandemic.
  • Understanding the clinical spectrum of COVID-19 is crucial for patient management.

Purpose of the Study:

  • To conduct a meta-analysis evaluating the prevalence of common symptoms and complications associated with COVID-19.
  • To identify the most frequent clinical manifestations and sequelae of COVID-19.

Main Methods:

  • Systematic literature search of PubMed and Scopus databases for studies on COVID-19 clinical complications.
  • Meta-analysis of data from 30 selected studies, encompassing 6,389 infected patients.
  • Utilized a random-effects model in STATA (Version 14) for data analysis.

Main Results:

  • Prevalence of symptoms: Fever (84.30%), Cough (63.01%), Dyspnea (37.16%), Fatigue (34.22%), Diarrhea (11.47%).
  • Prevalence of complications: Acute Respiratory Distress Syndrome (ARDS) (33.15%), Arrhythmia (16.64%), Acute Cardiac Injury (15.68%), Heart Failure (11.50%), Acute Kidney Injury (AKI) (9.87%).

Conclusions:

  • Respiratory symptoms like fever and cough are highly prevalent in COVID-19.
  • Cardiac and renal complications frequently follow initial respiratory manifestations of COVID-19.

Keywords:
ARDSCOVID-19acute cardiac injuryacute kidney injury (AKI)

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