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Chemoimmunotherapy for the salvage treatment of Ewing sarcoma: A case report
Deniz Can Guven1, Saadettin Kilickap2, Hasan Cagri Yildirim1
1Department of Medical Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.
Introduction:
Although, immune check-point inhibitors changed the course of many cancers, the outcomes in sarcomas were rather disappointing with less than 10% response rates. Ewing sarcoma is a poorly differentiated and aggressive tumor mostly seen in the children and adolescents. It's a distinct type of sarcoma with prominent chemosensitivity in the early stages. However, the relapsing disease has a poor prognosis with limited treatment options.
Case Report:
Herein, we represent a case of relapsed Ewing sarcoma treated with multiple lines of chemotherapy.Management & outcome: The patient had a very good response to salvage treatment with a combination of paclitaxel and nivolumab which lasted for twelve months after the cessation of treatment.
Discussion:
We think that chemotherapy plus immunotherapy can be an option for Ewing sarcoma patients treated with multiple lines of chemotherapy.
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