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Related Experiment Video

Updated: Dec 5, 2025

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Rapid Fabrication of Custom Microfluidic Devices for Research and Educational Applications

Published on: November 20, 2019

A practical guide to rapid-prototyping of PDMS-based microfluidic devices: A tutorial.

Giorgio Gianini Morbioli¹, Nicholas Colby Speller¹, Amanda M Stockton¹

¹School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, 30332, USA.

Analytica Chimica Acta

|October 19, 2020

Summary

This summary is machine-generated.

This tutorial explores rapid prototyping for micro total analytical systems (μTAS) using polydimethylsiloxane (PDMS). It compares techniques like soft-lithography to accelerate μTAS development, reducing costs and fabrication time.

Keywords:

3D-printing Microfabrication Polydimethylsiloxane (PDMS)Print-and-peel (PAP)Scaffolding Soft-lithography

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Last Updated: Dec 5, 2025

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High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

High Throughput Microfluidic Rapid and Low Cost Prototyping Packaging Methods

Published on: December 23, 2013

Area of Science:

Microfluidics
Analytical Chemistry
Biomedical Engineering

Background:

Micro total analytical systems (μTAS) offer portability, automation, and reduced consumption, making them valuable across chemistry, medicine, and engineering.
Conventional microfabrication of μTAS is time-consuming, requires skilled personnel, and relies on expensive cleanroom facilities, hindering widespread adoption.
Polydimethylsiloxane (PDMS) and rapid prototyping offer a cost-effective and faster alternative for developing microfluidic devices.

Purpose of the Study:

To provide a tutorial on current rapid prototyping techniques for fabricating PDMS-based microdevices.
To compare different rapid prototyping methods based on feature resolution, fabrication process, and cost.
To offer insights into the iterative design, fabrication, and testing process for optimizing μTAS development.

Main Methods:

Review and comparison of established rapid prototyping techniques for PDMS microdevices.
Discussion of methods including soft-lithography, print-and-peel, and scaffolding.
Analysis of fabrication parameters, resolution capabilities, and cost-effectiveness.

Main Results:

Identification of advantages and disadvantages for each rapid prototyping technique.
Comparative data on feature resolution, process complexity, and associated expenses.
Insights into optimizing the iterative microfabrication workflow.

Conclusions:

Rapid prototyping significantly reduces the cost and time required for developing PDMS-based microfluidic devices.
Choosing the appropriate rapid prototyping technique is crucial for efficient μTAS development.
Further optimization of the iterative process can accelerate the creation of functional μTAS.