Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

755
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
755
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

663
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
663
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

664
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
664
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

1.3K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.3K
Gastrointestinal Motility Disorders01:20

Gastrointestinal Motility Disorders

892
Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...
892
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

531
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
531

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Floristic Diversity and Indicator Species Analysis Along Altitudinal Gradients of the Upper Indus Basin, Northern Pakistan.

Ecology and evolution·2026
Same author

Phytosociological analysis and floristic composition of fabaceae species assessing human impact and edaphic variables.

Scientific reports·2026
Same author

Correction: An olive oil-derived NAE mixture (Olaliamid<sup>®</sup>) improves liver and cardiovascular health, and decreases meta-inflammation in naturally obese dogs: a double-blind, randomized, placebo-controlled study.

BMC veterinary research·2025
Same author

Endovascular thrombectomy for large vessel occlusion in acute ischemic stroke patients with concomitant intracranial hemorrhage.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia·2025
Same author

Tree-ring maximum latewood density reveals unprecedented warming and long-term summer temperature in the upper Indus Basin, northern Pakistan.

The Science of the total environment·2024
Same author

Innovations in Artificial Intelligence-Driven Breast Cancer Survival Prediction: A Narrative Review.

Cancer informatics·2024

Related Experiment Video

Updated: Dec 5, 2025

Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice
04:29

Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice

Published on: September 19, 2019

6.6K

Traumatic brain injury causing intestinal dysfunction: A review.

Pulwasha M Iftikhar1, Arsalan Anwar2, Sidra Saleem2

  • 1Department of Health Sciences, St John's University, New York, United States.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|October 19, 2020
PubMed
Summary
This summary is machine-generated.

Traumatic brain injuries (TBI) can lead to serious health issues and impact gut function. Early diagnosis of intestinal dysfunction following TBI is crucial for better patient outcomes and reduced healthcare costs.

Keywords:
Brain-gut axisInflammationIntestinal dysfunctionTraumatic brain injury

More Related Videos

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:27

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

732
Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.5K

Related Experiment Videos

Last Updated: Dec 5, 2025

Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice
04:29

Investigating Alterations in Caecum Microbiota After Traumatic Brain Injury in Mice

Published on: September 19, 2019

6.6K
Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
08:27

Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging

Published on: April 11, 2025

732
Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.5K

Area of Science:

  • Neuroscience
  • Gastroenterology
  • Public Health

Background:

  • Traumatic brain injuries (TBI) are a significant global health concern, increasing morbidity and mortality.
  • Primary brain insult can cause secondary complications affecting multiple organ systems, including the gut.
  • Gut dysfunction following TBI is an underrecognized issue with substantial healthcare costs due to delayed diagnosis.

Purpose of the Study:

  • To review existing literature on the relationship between traumatic brain injury and intestinal dysfunction.
  • To highlight the epidemiology, pathophysiology, and diagnostic approaches for gut dysfunction post-TBI.
  • To emphasize the importance of early diagnosis for improved patient outcomes and reduced healthcare burden.

Main Methods:

  • Comprehensive literature review of studies involving both human and animal models.
  • Analysis of epidemiological data, pathophysiological mechanisms, and diagnostic strategies.
  • Synthesis of findings to provide a holistic understanding of TBI-associated gut dysfunction.

Main Results:

  • TBI can trigger secondary pathways leading to widespread systemic complications, including significant gut dysfunction.
  • Epidemiological data indicates a growing prevalence of TBI and its associated sequelae.
  • Current diagnostic approaches for gut dysfunction post-TBI require further refinement for timely identification.

Conclusions:

  • The link between TBI and intestinal dysfunction is a critical area requiring increased attention.
  • Early and accurate diagnosis of gut dysfunction is essential for mitigating secondary complications and improving patient recovery.
  • Further research is needed to develop standardized diagnostic tools and therapeutic strategies for TBI-related gut issues.