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Related Experiment Video

Updated: Dec 5, 2025

Murine Model of Allergen Induced Asthma

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Physiologically variable ventilation in a rabbit model of asthma exacerbation.

André Dos Santos Rocha¹, Roberta Südy¹, Ferenc Peták²

¹Unit for Anaesthesiological Investigations, Department of Acute Medicine, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland.

British Journal of Anaesthesia

|October 19, 2020

Summary

Physiologically variable ventilation (PVV) improved gas exchange and reduced lung injury in a severe asthma model compared to pressure-controlled ventilation (PCV). PVV offers a promising alternative for mechanical ventilation in status asthmaticus.

Keywords:

gas exchange lung injury mechanical ventilation respiratory mechanics status asthmaticus

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Last Updated: Dec 5, 2025

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Area of Science:

Pulmonary Medicine
Critical Care Medicine
Respiratory Physiology

Background:

Mechanical ventilation in status asthmaticus poses significant challenges and risks.
Physiologically variable ventilation (PVV) has shown promise in healthy and injured lungs.

Purpose of the Study:

To investigate the benefits of PVV compared to pressure-controlled ventilation (PCV) in an experimental model of severe acute asthma.

Main Methods:

Allergen-sensitized rabbits underwent mechanical ventilation with either PCV or PVV for 6 hours.
Ventilation parameters, oxygenation, respiratory mechanics, and histological lung injury were assessed.

Main Results:

PVV demonstrated significantly lower driving pressures and improved oxygenation index (PaO2/FiO2) compared to PCV.
PVV maintained tissue elastance, reduced histological lung injury scores, and decreased inflammatory cell counts and protein concentration in bronchoalveolar lavage fluid.

Conclusions:

PVV application in a model of asthma exacerbation improved gas exchange, ventilatory pressures, and respiratory mechanics while reducing lung injury.
Reduced lung shear stress and improved recruitment effects likely contribute to PVV's benefits in status asthmaticus.