Multicomponent Reactions: "Kinderleicht"
Constantinos G Neochoritis1,2, Tryfon Zarganes-Tzitzikas1, Kallia Katsampoxaki-Hodgetts2
1Drug Design Group, Department of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen 9700 AV, The Netherlands.
Abstract:
A demonstration experiment of the synthesis of a novel tetrazole derivative via a multicomponent reaction (Ugi tetrazole four component reaction, UT-4CR) bearing a luminol moiety and a subsequent exploitation of its chemiluminescent properties is described. A complex product is generated in just one simple step, so simple that children can do it: "kinderleicht", German for dead easy. Students are stimulated, inspired, and involved in a multilevel active learning process using the Steps to Inquiry framework as a metacognitive tool that raises student awareness regarding scientific process and prompts them to ask their own questions discussing the merits of a mechanism and evaluating its effectiveness before they start their own cycles of inquiry.
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