Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Reaction Mechanisms03:06

Reaction Mechanisms

29.9K
Chemical reactions often occur in a stepwise fashion, involving two or more distinct reactions taking place in a sequence. A balanced equation indicates the reacting species and the product species, but it reveals no details about how the reaction occurs at the molecular level. The reaction mechanism (or reaction path) provides details regarding the precise, step-by-step process by which a reaction occurs.
For instance, the decomposition of ozone appears to follow a mechanism with two steps:
29.9K
Multi-Step Reactions02:31

Multi-Step Reactions

8.3K
Chemical reactions often occur in a stepwise fashion involving two or more distinct reactions taking place in a sequence. A balanced equation indicates the reacting species and the product species, but it reveals no details about how the reaction occurs at the molecular level. The reaction mechanism (or reaction path) provides details regarding the precise, step-by-step process by which a reaction occurs. Each of the steps in a reaction mechanism is called an elementary reaction. These...
8.3K
Coupled Reactions01:17

Coupled Reactions

10.1K
Cellular processes such as building and breaking down complex molecules occur through stepwise chemical reactions. Some of these chemical reactions are spontaneous and release energy, whereas others require energy to proceed. Cells often couple the energy-releasing reaction with the energy-requiring one to carry out important cell functions. 
Energy in adenosine triphosphate or ATP molecules is easily accessible to do work. ATP powers the majority of energy-requiring cellular reactions....
10.1K
Introduction to Chemical Reactions01:23

Introduction to Chemical Reactions

11.3K
All chemical reactions begin with a reactant, the general term for one or more substances entering the reaction. Sodium and chloride ions, for example, are the reactants in the production of table salt. One or more substances produced by a chemical reaction are called the product. Chemical reactions follow the law of conservation of mass, which means that matter cannot be created nor destroyed in a chemical reaction. The components of the reactants—the number of atoms and the...
11.3K
Chemical Reactions01:19

Chemical Reactions

94.4K
A chemical reaction is a process by which the bonds in the atoms of substances are rearranged to generate new substances. Matter cannot be created or destroyed in a chemical reaction—the same type and number of atoms that make up the reactants are still present in the products. Merely, the rearrangement of chemical bonds produces new compounds.
Chemical Reactions Rearrange Atoms into New Substances
A chemical reaction takes starting materials—the reactants—and changes them...
94.4K
Chemical Reactions02:26

Chemical Reactions

13.0K
A balanced chemical equation provides the information of chemical formulas of the reactants and products involved in the chemical change. A reaction’s stoichiometry helps predict how much of the reactant is needed to produce the desired amount of product, or in some cases, how much product will be formed from a specific amount of the reactant.
The relative amounts of reactants and products represented in a balanced chemical equation are often referred to as stoichiometric amounts. However, in...
13.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Geometry-dependent interfaces shape NLRP3 pyrin domain assembly.

International journal of biological macromolecules·2026
Same author

An Ugi-Joullié Platform for Medicinally Relevant 1,4-Dihydrobenzothiazines.

ChemMedChem·2026
Same author

One Face, Three Solutions: Structural Convergence in PD-L1 Inhibition across Antibodies, Macrocycles, and Small Molecules.

Journal of medicinal chemistry·2026
Same author

Pleural fluid neutrophil extracellular traps are associated with disease severity and risk of one-year mortality in pleural infection. An observational, international, multicohort study (TORPIDS-3).

The European respiratory journal·2026
Same author

Baxdrostat: A First-in-Class Aldosterone Synthase Inhibitor for Resistant Hypertension.

ACS pharmacology & translational science·2026
Same author

Ugi-Tetrazole-Derived α‑Aminomethyl Scaffolds Reveal Unexpected Binding Modes in SARS-CoV‑2 3CLpro.

ACS medicinal chemistry letters·2026

Related Experiment Video

Updated: Dec 5, 2025

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

25.8K

Multicomponent Reactions: "Kinderleicht".

Constantinos G Neochoritis1,2, Tryfon Zarganes-Tzitzikas1, Kallia Katsampoxaki-Hodgetts2

  • 1Drug Design Group, Department of Pharmacy, University of Groningen, A. Deusinglaan 1, Groningen 9700 AV, The Netherlands.

Journal of Chemical Education
|October 19, 2020
PubMed
Summary

Researchers synthesized a novel tetrazole derivative using a simple Ugi tetrazole four-component reaction (UT-4CR). This new compound exhibits chemiluminescent properties, demonstrating a straightforward synthesis for educational purposes.

More Related Videos

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
07:36

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Published on: November 9, 2019

8.3K
Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators
06:31

Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators

Published on: November 27, 2015

9.8K

Related Experiment Videos

Last Updated: Dec 5, 2025

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions
11:44

Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-phosphinetriyltripiperidine]}palladium Under Mild Reaction Conditions

Published on: March 20, 2014

25.8K
Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
07:36

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Published on: November 9, 2019

8.3K
Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators
06:31

Highly Stereoselective Synthesis of 1,6-Ketoesters Mediated by Ionic Liquids: A Three-component Reaction Enabling Rapid Access to a New Class of Low Molecular Weight Gelators

Published on: November 27, 2015

9.8K

Area of Science:

  • Organic Chemistry
  • Chemical Education

Background:

  • Multicomponent reactions offer efficient synthetic pathways.
  • Chemiluminescent compounds like luminol have diverse applications.
  • Inquiry-based learning enhances scientific understanding.

Purpose of the Study:

  • To demonstrate a novel tetrazole derivative synthesis using the Ugi tetrazole four-component reaction (UT-4CR).
  • To explore the chemiluminescent properties of the synthesized tetrazole derivative.
  • To develop an engaging and accessible experiment for science education.

Main Methods:

  • Synthesis of a novel tetrazole derivative incorporating a luminol moiety via UT-4CR.
  • Characterization of the synthesized compound.
  • Evaluation of the chemiluminescent properties of the product.

Main Results:

  • Successful synthesis of a complex tetrazole derivative in a single step.
  • The novel compound exhibits notable chemiluminescent properties.
  • The experiment is designed to be highly accessible and engaging for students.

Conclusions:

  • The UT-4CR provides an efficient route to novel chemiluminescent tetrazole derivatives.
  • This experiment serves as an effective tool for inquiry-based learning in chemistry.
  • The study highlights the potential for integrating advanced synthesis with educational outreach.