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The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
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Respiratory symptoms, such as congestion and cough, commonly accompany respiratory tract conditions. Various medications, such as antitussives, expectorants, and mucolytics, play crucial roles in providing relief.
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Related Experiment Video

Updated: Dec 5, 2025

Method of Studying Palatal Fusion using Static Organ Culture
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ANTENATAL EVENTS AMONGST MOTHERS OF BABIES WITH OROFACIAL CLEFTS.

A A Olusanya1, A I Michael2, O A Olawoye2,3

  • 1Department of Oral and Maxillofacial Surgery, College of Medicine, University of Ibadan, Nigeria.

Annals of Ibadan Postgraduate Medicine
|October 19, 2020
PubMed
Summary

This study found no specific antenatal factors contributing to orofacial clefts despite high antenatal care uptake. Further research is needed to identify causes of these birth defects.

Keywords:
Antenatal eventsCleft lip and palateMothers

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Area of Science:

  • Medical Research
  • Public Health
  • Genetics

Background:

  • Orofacial clefts are common birth defects potentially influenced by antenatal factors.
  • Identifying these factors is crucial for prevention strategies.

Purpose of the Study:

  • To investigate antenatal events in mothers that may contribute to orofacial cleft deformities in their offspring.
  • To determine potential links between maternal health behaviors and orofacial clefts.

Main Methods:

  • Prospective observational cross-sectional study involving mothers of infants with orofacial clefts.
  • Data collected via questionnaires from consenting mothers.

Main Results:

  • 72 mothers participated; most were under 35 and of low-intermediate socioeconomic status.
  • High antenatal care (97.2%) and ultrasound use (95.8%) were observed, but cleft detection was low (2.8%).
  • Commonly used medications included haematinics (36.1%), herbal remedies (20.8%), and antimalarials (16.7%).

Conclusions:

  • High utilization of antenatal services was noted among mothers of infants with orofacial clefts.
  • No specific antenatal predisposing factors were identified in this study.
  • The etiology of orofacial clefts remains multifactorial and requires further investigation.