Oxytocin Receptor Signaling in Vascular Function and Stroke
Erin C McKay1,2, Scott E Counts1,2,3,4,5
1Department of Translational Neuroscience, Michigan State University, Grand Rapids, MI, United States.
Frontiers in Neuroscience
|October 19, 2020
Summary
The oxytocin receptor (OXTR) plays a key role in cell signaling. This review explores OXTR
Area of Science:
- Neuroscience
- Molecular Biology
- Pharmacology
Background:
- The oxytocin receptor (OXTR) is a G protein-coupled receptor.
- It mediates cellular responses to oxytocin (OXT) and vasopressin.
- OXTR signaling involves diverse intracellular pathways.
Purpose of the Study:
- To review the cell and molecular biology of the OXTR.
- To focus on the vasoactive functions of OXTR signaling.
- To explore clinical applications of OXTR targeting in cerebrovascular accidents.
Main Methods:
- Literature review of cell and molecular biology studies.
- Analysis of research on OXTR signaling pathways.
- Examination of studies on OXTR in human and animal models.
- Review of clinical research on OXTR targeting for cerebrovascular accidents.
Main Results:
- OXTR activation triggers a range of intracellular signaling cascades.
- OXTR signaling exhibits significant vasoactive functions in various models.
- OXTR targeting presents potential therapeutic strategies for cerebrovascular accidents.
Conclusions:
- Understanding OXTR cell and molecular biology is crucial.
- OXTR's vasoactive roles highlight its physiological importance.
- Targeting OXTR offers promising avenues for treating cerebrovascular conditions.
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