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Related Experiment Video

Updated: Dec 5, 2025

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

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Synaptoprotection in Perinatal Asphyxia: An Experimental Approach.

María Inés Herrera1,2,3, Tamara Kobiec1,2,3, Rodolfo Kölliker-Frers2,3

  • 1Centro de Investigaciones en Psicología y Psicopedagogía (CIPP), Facultad de Psicología y Psicopedagogía, Universidad Católica Argentina (UCA), Buenos Aires, Argentina.

Frontiers in Synaptic Neuroscience
|October 19, 2020
PubMed
Summary

Perinatal asphyxia (PA) can harm newborns by disrupting brain function and leading to neurodevelopmental issues. Synaptoprotection strategies, alongside therapeutic hypothermia, show promise in mitigating these effects.

Keywords:
animal modelneuroprotective strategiesperinatal asphyxiasynaptopathysynaptoprotection

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Last Updated: Dec 5, 2025

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Area of Science:

  • Neuroscience
  • Neonatal Medicine
  • Obstetrics

Background:

  • Perinatal asphyxia (PA) is a critical obstetric complication impacting neonates, causing significant brain damage and high mortality.
  • PA leads to neuronal loss in key brain areas and neurodevelopmental disabilities in survivors.
  • Synaptic dysfunction is a central pathological feature of PA.

Purpose of the Study:

  • To review the pathophysiology of perinatal asphyxia, focusing on synaptic derangement.
  • To evaluate current and potential neuroprotective strategies against PA-induced brain injury.
  • To highlight synaptoprotection as a therapeutic target for reducing neurodevelopmental disorders.

Main Methods:

  • Utilized an animal model that mimics intrauterine asphyxia to study PA.
  • Reviewed experimental and clinical data on therapeutic hypothermia (TH) and pharmacological agents.
  • Analyzed morphological and biochemical pathways involved in PA.

Main Results:

  • PA causes significant synaptic derangement, affecting neuronal structure and function.
  • Therapeutic hypothermia (TH) is the only established treatment with positive clinical outcomes.
  • Various pharmacological agents are under investigation for their synaptoprotective potential.

Conclusions:

  • Synaptic dysfunction is a critical target for neuroprotection in perinatal asphyxia.
  • Synaptoprotection offers a promising strategy to reduce neurodevelopmental disorders post-PA.
  • Further research into pharmacological agents is crucial for developing novel treatments.