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Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia

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Published on: November 9, 2018

Astrocytes in Tauopathies.

Matthew J Reid¹, Paula Beltran-Lobo¹, Louisa Johnson¹

¹Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.

Frontiers in Neurology

|October 19, 2020

Summary

Pathological tau aggregates in the brain are linked to tauopathies. Astrocytes play a key role in tau uptake and spread, impacting neurodegeneration and offering potential therapeutic targets.

Keywords:

Alzheimer's disease astrocyte glia prion-like propagation tau tauopathy

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Published on: November 14, 2020

Area of Science:

Neuroscience
Cell Biology
Pathology

Background:

Tauopathies involve progressive accumulation of hyperphosphorylated tau aggregates in the brain.
Astrocytes, crucial for neuronal function and brain barriers, have an incompletely understood role in tauopathy progression.

Purpose of the Study:

To review the association of tau with astrocytes in tauopathies.
To discuss the role of astrocytes in pathological tau uptake, spread, and potential neurotoxicity.

Main Methods:

Literature review of studies examining tau pathology and astrocyte involvement.
Analysis of findings on astrocyte phenotype alterations in tauopathies.

Main Results:

Evidence suggests astrocytes contribute to the uptake and propagation of pathological tau.
Altered astrocyte function in tauopathies can impair neuronal support and potentially cause neurotoxicity.

Conclusions:

Astrocytes are implicated in tauopathy progression through tau uptake and spread.
Targeting astrocytes may offer novel therapeutic strategies for tauopathies, highlighting the importance of non-neuronal cells in neurodegeneration.