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The interplay between EBV and KSHV viral products and NF-κB pathway in oncogenesis

J Charostad1,2, M Nakhaie1,3, A Dehghani1

  • 1Department of Medical Virology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Infectious Agents and Cancer
|October 19, 2020
PubMed

Insights

Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV) can cause cancer by disrupting the NF-κB signaling pathway. Understanding this link is key to developing new cancer therapies.

Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • Epstein-Barr virus (EBV) and Kaposi sarcoma herpesvirus (KSHV) are DNA tumor viruses linked to significant cancer burdens.
  • Dysregulation of transcription factor signaling pathways is a key oncogenic feature of EBV and KSHV infections.

Purpose of the Study:

  • To clarify the relationship between NF-κB signaling pathway dysregulation and EBV/KSHV-related malignancies.
  • To highlight the role of viral products in cancer development via NF-κB pathway alteration.

Main Methods:

  • Literature review of recent findings on EBV, KSHV, and NF-κB signaling.
  • Analysis of the mechanisms by which these viruses target the NF-κB cascade.

Main Results:

  • Constitutive activation of NF-κB is common in human cancers.
  • Both EBV and KSHV are shown to target various components of the NF-κB signaling pathway.
  • Viral products contribute to oncogenesis by altering NF-κB signaling.

Conclusions:

  • Dysregulation of the NF-κB pathway is a critical factor in EBV and KSHV-associated cancers.
  • Targeting viral interference with NF-κB signaling may offer therapeutic strategies for virus-driven malignancies.
Keywords:
EBVKSHVNF-κBNeoplasm

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