[Immunology of fetomaternal interaction: HLA antigens]

The histocompatibility complex is an essential part of the immunology of the fetomaternal interactions. HLA antigen haplotyps are present on fetal lymphocytes. HLA antigens are also localized in the chorion. The paternal HLA antigenicity is decreased by different mechanism. In multiparae HLA antibodies are detectable in 20 to 30 per cent without injuries of the fetal tissues or wellbeing respectively. The placenta possesses the ability of the immunoadsorption of maternal lymphocytotoxic antibodies. In cases of increased compatibility of materno-paternal HLA antigens habitual abortions are more frequent according to some authors. Therapeutic leucocyte transfusion can be used regarding to prevention of recurrent abortions.