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Impact of Tablet Shape on Drug Dissolution Rate Through Immediate Released Tablets
Fatima Molavi1, Hamed Hamishehkar2, Ali Nokhodchi3
1Biotechnology Research Center, Student Research Committee and Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
Advanced Pharmaceutical Bulletin
|October 19, 2020
Summary
Tablet shape significantly impacts drug dissolution rates. Biconvex domperidone tablets show higher dissolution efficiency than flat ones, influencing drug release kinetics for faster action.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Physical Pharmacy
Background:
- Dissolution rate is critical for immediate-release dosage forms.
- Limited data exists on how drug geometric shape affects dissolution.
- Domperidone serves as a model drug for this investigation.
Purpose of the Study:
- To evaluate the influence of geometric shape on domperidone dissolution rate.
- To investigate the relationship between tablet size, shape, and drug release.
- To understand the impact of these factors on drug release kinetics.
Main Methods:
- Modeling of three tablet shapes (flat, round biconvex, oblong biconvex) in four sizes.
- In vitro dissolution testing using USP dissolution apparatus II.
- Calculation of dissolution parameters: dissolution efficiency (DE), mean dissolution rate (MDR), mean dissolution time (MDT), f1, and f2.
Main Results:
- Larger tablets exhibited faster disintegration times.
- Smaller tablet sizes resulted in significantly decreased drug release.
- Biconvex tablets generally demonstrated higher dissolution efficiency (DE) than flat tablets.
- Tablet geometry (flat vs. biconvex) notably affected DE values.
Conclusions:
- Geometric shape and size significantly influence domperidone dissolution parameters.
- Biconvex shapes enhance drug release compared to flat shapes.
- These findings are crucial for optimizing oral drug administration and achieving a rapid onset of action.
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