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Perforated and Endothelialized Elastomeric Tubes for Vascular Modeling.

Margaux Duchamp1, Syeda Mahwish Bakht1, Jie Ju1

  • 1Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.

Advanced Materials Technologies
|October 19, 2020
PubMed
Summary
This summary is machine-generated.

Researchers developed a novel polydimethylsiloxane (PDMS) platform with pores for creating blood vessel models. This innovation facilitates in vitro vascular modeling and aids in studying angiogenesis and therapeutic screening.

Keywords:
endothelial cellspolydimethylsiloxane (PDMS)tumor spheroidsvascular modelvascularization

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Area of Science:

  • Biomaterials Engineering
  • Vascular Biology
  • Tissue Engineering

Background:

  • Accurate in vitro models of human vasculature are crucial for understanding physiological and pathological processes.
  • Existing models often lack the complexity to replicate the dynamic interactions within microvasculature.
  • Polydimethylsiloxane (PDMS) is a versatile material for creating microfluidic devices.

Purpose of the Study:

  • To develop a novel tubular PDMS platform with pores for in vitro blood vessel modeling.
  • To investigate the formation of microvascular networks and tumor angiogenesis using this platform.
  • To provide a tool for improved biological studies and therapeutic screening.

Main Methods:

  • Fabrication of tubular PDMS structures using a templating approach.
  • Generation of pores on the PDMS tube walls via focused laser ablation.
  • Seeding endothelial cells and embedding the tubes in an extracellular matrix (ECM)-like environment.
  • Co-culturing with tumor spheroids to observe angiogenesis.

Main Results:

  • Successful creation of perforated PDMS tubes capable of supporting endothelial cell growth.
  • Formation of interconnected microvascular networks dependent on flow dynamics within the tubes.
  • Observation of tumor angiogenesis when co-cultured with tumor spheroids.
  • Demonstration of endothelial cell sprouting through pores into the surrounding matrix.

Conclusions:

  • The perforated PDMS tubes provide a convenient and effective platform for in vitro vascular modeling.
  • This model system can be used to study microvasculature formation and tumor angiogenesis.
  • The platform holds potential for advancing biological research and facilitating therapeutic screening.