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Related Experiment Video

Updated: Dec 5, 2025

Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research
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3D Immunocompetent Organ-on-a-Chip Models.

Sushila Maharjan1, Berivan Cecen1, Yu Shrike Zhang1

  • 1Division of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.

Small Methods
|October 19, 2020
PubMed
Summary

Organs-on-chips (OOCs) are advanced in vitro models, but often lack immune cells. New immunocompetent OOCs are being developed to better model human tissues and diseases by incorporating immune system components.

Keywords:
extracellular matriximmune cellimmunocompetentmicroenvironmentorgan-on-a-chip

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Area of Science:

  • Biomedical Engineering
  • Immunology
  • Tissue Engineering

Background:

  • Organs-on-chips (OOCs) are microphysiological systems designed to mimic human organ functions in vitro.
  • Existing OOC models often neglect the crucial role of immune cells in tissue homeostasis and disease pathology.
  • There is a growing need for OOC models that accurately represent the complex cellular interactions within native tissues.

Purpose of the Study:

  • To review the progress in developing immunocompetent OOC platforms.
  • To highlight the importance of immune cell integration in OOC models.
  • To discuss challenges and future directions for immune-inclusive OOC development.

Main Methods:

  • Review of current literature on immune cell incorporation into OOC systems.
  • Discussion of various immunocompetent OOC approaches and platforms.
  • Analysis of how immune components influence tissue function and disease modeling in OOCs.

Main Results:

  • Significant advancements have been made in creating OOC models that include immune cells.
  • These immunocompetent OOCs enable the study of cell-cell interactions (parenchymal, vascular, immune) and extracellular matrix.
  • OOC models can investigate the impact of tissue architecture and dynamic forces on function and disease.

Conclusions:

  • Incorporating immune cells into OOCs is essential for creating more physiologically relevant in vitro models.
  • Immune-inclusive OOCs offer powerful tools for studying tissue homeostasis, disease mechanisms, and drug testing.
  • Further research is needed to overcome challenges in fully recreating functional, immunocompetent tissue systems in vitro.