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Updated: Dec 5, 2025

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

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CONCORDE: A phase I platform study of novel agents in combination with conventional radiotherapy in non-small-cell

Gerard M Walls1, Jamie B Oughton2, Anthony J Chalmers3

  • 1Patrick G Johnston Centre for Cancer Research, Queen's University Belfast, Northern Ireland, UK.

Clinical and Translational Radiation Oncology
|October 19, 2020
PubMed

Keywords:
ATM, Ataxia telangiectasia mutatedATR, Ataxia telangiectasia and Rad3 relatedCRT, ChemoradiotherapyCT, Computed tomographyCTCAE, Common terminology criteria for adverse eventsCTRad, Clinical and Translational Radiotherapy Research Working GroupContinual reassessment methodDDRi, DNA damage response inhibitorDLT, Dose limiting toxicityDNA damage repair inhibitorDNA, Deoxyribonucleic acidDNA-PK, DNA-dependent protein kinaseECOG, Eastern Cooperative Oncology GroupEORTC, European Organisation for Research and Treatment of CancerICRU, International Commission on Radiation Units and MeasurementsIMPs, Investigational medicinal productsLA, Locally advancedMRC, Medical Research CouncilNCRI, National Cancer Research InstituteNSCLC, Non-small cell lung cancerNon-small cell lung cancerPARP, Poly (ADP-ribose) polymerasePET, Positron emission tomographyPFS, Progression free survivalPROMs, Patient-reported outcome measuresPlatform trialRECIST, Response evaluation criteria in solid tumoursRP2D, Recommended phase II doseRT, RadiotherapySACT, Systemic anti-cancer therapySRC, Safety review committeeSequential chemoradiotherapyTNM, Tumour node metastasisTiTE-CRM, Time to event continual reassessment methodcfDNA, Cell-free DNA

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