Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Merkel cell tumor.

M Kitazawa, H Watanabe, H Kobayashi

    Acta Pathologica Japonica
    |June 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Three-dimensional analysis of eye movements induced by roll and pitch tilt].

    Nihon Jibiinkoka Gakkai kaiho·2000
    Same author

    Three dimensional eye movement analysis during off vertical axis rotation in human subjects.

    Archives italiennes de biologie·1999
    Same author

    Three-dimensional analysis of pressure nystagmus in labyrinthine fistulae.

    Acta oto-laryngologica·1999
    Same author

    Cadmium, lead, and zinc concentrations in human fingernails.

    Bulletin of environmental contamination and toxicology·1993
    Same author

    Effects of fasting on distribution and excretion of lead following long-term lead exposure in rats.

    Archives of environmental contamination and toxicology·1993
    Same author

    [Expandable metallic stent therapy for SVC syndrome--effects on local venous pressure, vascular diameter, symptoms, and these correlations].

    Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica·1992
    Same journal

    One step procedure of PCR-DNA extraction from paraffin-embedded materials by Chelex-100.

    Acta pathologica japonica·1993
    Same journal

    Primary hepatic carcinoid tumor.

    Acta pathologica japonica·1993
    Same journal

    Hepatocellular carcinoma with unusual metastasis to the small intestine.

    Acta pathologica japonica·1993
    Same journal

    Polymorphous low-grade adenocarcinoma of submandibular gland origin.

    Acta pathologica japonica·1993
    Same journal

    Two cases of recurrent hepatic injury associated with early pregnancy: hCG on hepatocytes is a suspected target antigen for lymphocyte attack.

    Acta pathologica japonica·1993
    Same journal

    Distribution of laminin, type IV collagen and fibronectin in the invasive component of breast carcinoma.

    Acta pathologica japonica·1993
    See all related articles

    This study reports a Merkel cell tumor case, highlighting its neuroendocrine and epithelial differentiation. Electron microscopy and immunohistochemistry confirmed its dual origin, offering insights into this rare cancer.

    Area of Science:

    • Oncology
    • Dermatopathology
    • Cell Biology

    Background:

    • Merkel cell carcinoma (MCC) is a rare and aggressive skin cancer with neuroendocrine features.
    • Understanding the cellular origin and differentiation pathways of MCC is crucial for diagnosis and treatment.

    Observation:

    • A Merkel cell tumor presented on the left cheek of an 83-year-old female patient.
    • Histopathological analysis revealed dermal and subcutaneous adipose tissue infiltration, involving peripheral blood vessels and lymphatics.
    • Electron microscopy identified dense-cored granules and intermediate filament aggregates, with positive uranaffin reaction on granules.

    Findings:

    • Tumor cells exhibited a mixed cytoplasmic border (smooth and projected) without desmosomes or junctional complexes.
    • Immunohistochemistry showed positive staining for neuron-specific enolase (NSE) and keratin.

    Related Experiment Videos

  • Keratin-positive spots colocalized with intermediate filament aggregates, supporting a dual differentiation.

    • Implications:

    • These findings suggest a neurogenic origin for Merkel cell tumors with concurrent epithelial and neuroendocrine differentiation.
    • This case contributes to the understanding of MCC's complex cellular biology.
    • Further research into MCC differentiation may lead to improved diagnostic markers and targeted therapies.