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Novel immunotherapy strategies for treatment of neuroendocrine neoplasms

Taymeyah Al-Toubah1, Mauro Cives2, Jonathan Strosberg1

  • 1Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, USA.

Translational Gastroenterology and Hepatology
|October 19, 2020
PubMed

Insights

Immunotherapy is a novel approach for neuroendocrine neoplasms (NENs). Recent studies explore checkpoint inhibitors and CAR T-cell therapy, showing promise for these aggressive cancers.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Neuroendocrine neoplasms (NENs) are a diverse group of tumors.
  • Aggressive neuroendocrine carcinomas (NECs) exhibit higher mutational burden and PD-L1 expression compared to well-differentiated tumors.
  • The therapeutic options for NENs are expanding, with immunotherapy emerging as a recent focus.

Purpose of the Study:

  • To review the immune landscape of NENs.
  • To summarize recent clinical investigations of immunotherapy in NENs.
  • To discuss future directions for NEN immunotherapy.

Main Methods:

  • Literature review of the immune microenvironment in NENs.
  • Analysis of recent clinical trial data for immunotherapeutic agents in NENs.
  • Exploration of emerging immunotherapeutic strategies.

Main Results:

  • Poorly differentiated NECs show increased PD-L1 expression, suggesting potential for immunotherapy.
  • Checkpoint inhibitors (anti-PD-1, anti-CTLA-4), bispecific antibodies, and CAR T-cell therapy are being investigated.
  • Early clinical studies are evaluating the efficacy and safety of these novel treatments in NENs.

Conclusions:

  • Immunotherapy represents a promising frontier in NEN treatment.
  • Further research is needed to elucidate the immune landscape and optimize immunotherapeutic strategies for NENs.
  • Personalized immunotherapy approaches may improve outcomes for NEN patients.
Keywords:
CAR-T cellsCarcinoid tumorsPD-1PD-L1immune checkpointsimmunotherapy

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