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Admission fasting plasma glucose is an independent risk factor for 28-day mortality in patients with COVID-19

Ping Yang1, Nan Wang1, Jingjing Wang1

  • 1Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Journal of Medical Virology
|October 19, 2020
PubMed

Insights

High blood glucose (hyperglycemia) in COVID-19 patients admitted to the hospital is linked to a higher risk of death within 28 days. Managing blood sugar levels may improve outcomes for these patients.

Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Hyperglycemia is frequently observed in severe COVID-19 cases.
  • Understanding the impact of admission glucose levels on COVID-19 patient outcomes is crucial.

Purpose of the Study:

  • To investigate the association between admission fasting plasma glucose (FPG) and 28-day mortality in hospitalized COVID-19 patients.
  • To identify independent predictors of mortality in this patient cohort.

Main Methods:

  • A single-center retrospective study included 263 adult COVID-19 patients.
  • Demographic and clinical data were collected and analyzed.
  • Multivariable Cox regression models were used to assess risk factors for 28-day mortality.

Main Results:

  • Over half of the patients (51.3%) had elevated admission FPG (>7.0 mmol/L).
  • Admission FPG levels (7.0-11.0 mmol/L and ≥11.1 mmol/L), advanced age, chronic obstructive pulmonary disease, and cardiac injury were independent predictors of 28-day mortality.
  • Patients with diabetes had significantly higher FPG and experienced more fatal complications.

Conclusions:

  • Admission hyperglycemia is a significant predictor of worse outcomes in hospitalized COVID-19 patients.
  • Intensive glucose monitoring and glycemic control are recommended to potentially improve prognosis.

Keywords:
COVID-19diabeteshyperglycemiamortalityrisk factors

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