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Bioprinting of Collagen: Considerations, Potentials, and Applications
Jia Min Lee1, Sean Kang Qiang Suen1, Wei Long Ng2
1Singapore Centre for 3D Printing, School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore, 639798, Singapore.
Macromolecular Bioscience
|October 19, 2020
Summary
This review explores the challenges and strategies for printing pure collagen, a key material in tissue engineering (TE). Understanding collagen assembly and sources is crucial for advancing TE applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Bioprinting
Background:
- Collagen is the most abundant extracellular matrix protein, vital for tissue engineering applications.
- Pure collagen printing remains underexplored, hindering advancements in the field.
- A bottom-up approach is necessary to identify and overcome collagen printing challenges.
Purpose of the Study:
- To provide a comprehensive overview of collagen printing for tissue engineering.
- To understand collagen assembly in vivo and available collagen sources.
- To identify key challenges and future research directions in collagen printing.
Main Methods:
- Review of in vivo collagen assembly and sources.
- Analysis of current collagen printing technologies and strategies.
- Identification of considerations and challenges in printing pure collagen.
Main Results:
- The review details collagen assembly and various sources for tissue engineering.
- Current printing technologies and strategies for collagen-based materials are highlighted.
- Key challenges and considerations for printing pure collagen are identified.
Conclusions:
- Understanding collagen assembly and sources is fundamental for successful collagen printing.
- Addressing identified challenges is crucial for enhancing the functionality of printed collagen.
- Further research in key areas will advance the application of printed collagen in tissue engineering.
