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The Roles of γδ T Cells in Hematopoietic Stem Cell Transplantation

Wanyi Ye1, Xueting Kong1, Wenbin Zhang1

  • 1Institute of Hematology, School of Medicine, 47885Jinan University, Guangzhou, China.

Cell Transplantation
|October 19, 2020
PubMed

The αβ T-cell-depleted hematopoietic stem cell transplantation (HSCT) leads to lower relapse and better outcome, and may correlate strongly with expansion of donor-derived γδ T cells. γδ T cells play an important role in immune reconstitution and can exert a graft-versus-leukemia effect after HSCT. This review showed the recent literature on immune functions of γδ T cells after HSCT. The discrepancies between studies of γδ T cells in graft-versus-host disease may cause by its heterogeneous and various distinct subsets. And reconstitution of γδ T cells may play a potential immunoregulatory role in the infections after HSCT.

Keywords:
graft-versus-host diseasehematopoietic stem cell transplantationimmune functioninfectionγδ T cells

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