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Lipid based biocompatible ionic liquids: synthesis, characterization and biocompatibility evaluation.

Shihab Uddin1, Md Raihan Chowdhury, Rie Wakabayashi

  • 1Department of Applied Chemistry, Graduate School of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. m-goto@mail.cstm.kyushu-u.ac.jp.

Chemical Communications (Cambridge, England)
|October 19, 2020
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Researchers developed new biocompatible ionic liquids (LBILs) from fatty acids and a phosphonium compound. These novel LBILs show excellent miscibility and dispersibility, along with promising biocompatibility for potential applications.

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Area of Science:

  • Materials Science
  • Biochemistry
  • Chemical Engineering

Background:

  • Ionic liquids (ILs) are salts with low melting points, widely explored for diverse applications.
  • Biocompatibility is a critical factor for ILs intended for biological or medical use.
  • Developing novel ILs with tunable properties and enhanced safety profiles remains an active research area.

Purpose of the Study:

  • To synthesize and characterize a new class of lipid-based biocompatible ionic liquids (LBILs).
  • To evaluate the solubility and dispersibility of these LBILs in various solvents.
  • To assess the biocompatibility of the synthesized LBILs using an artificial human epidermis model.

Main Methods:

  • Synthesis of LBILs using 1,2-dimyristoyl-sn-glycero-3-ethyl-phosphatidylcholine as the cation and stearic, oleic, or linoleic acid as anions.
  • Solubility tests in polar and nonpolar organic solvents.
  • Dispersibility tests in water.
  • Biocompatibility assessment using a 3D artificial human epidermis model.

Main Results:

  • A series of novel LBILs were successfully synthesized.
  • The synthesized LBILs demonstrated complete miscibility with a wide range of organic solvents.
  • These LBILs were also found to be dispersible in water.
  • Excellent biocompatibility was observed with the artificial 3D human epidermis model.

Conclusions:

  • The newly developed LBILs possess favorable solubility and dispersibility characteristics.
  • The promising biocompatibility suggests potential for these LBILs in biomedical and pharmaceutical applications.
  • This study introduces a new platform of lipid-based ionic liquids with enhanced safety and versatility.