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Synthetic Investigation toward QS-21 Analogues
Zhi-Yong Zeng1, Jin-Xi Liao1, Zhen-Ni Hu1
1National Research Centre for Carbohydrate Synthesis, Jiangxi Normal University, 99 Ziyang Avenue, Nanchang 330022, China.
Organic Letters
|October 19, 2020
Abstract:
With glycosyl o-alkynylbenzotes as donors, a highly efficient protocol to construct the challenging glycosidic linkages at C3-OH of C23-oxo oleanane triterpenoids is disclosed, on the basis of which different strategies for the highly efficient synthesis of QS-21 analogues with the west-wing trisaccharide of QS-21 have been established.
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