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Factors associated with adverse COVID-19 outcomes in patients with psoriasis-insights from a global registry-based
Satveer K Mahil1, Nick Dand2, Kayleigh J Mason3
1St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, United Kingdom.
The Journal of Allergy and Clinical Immunology
|October 19, 2020
Summary
Patients with psoriasis on biologic treatments had a lower risk of COVID-19 hospitalization compared to those on nonbiologic therapies. Established risk factors like older age and male sex increased hospitalization risk.
Area of Science:
- Dermatology
- Infectious Diseases
- Epidemiology
Background:
- Psoriasis patients on immunosuppressants may face higher risks from COVID-19.
- Limited data exists on COVID-19 outcomes in this population.
Purpose of the Study:
- Characterize COVID-19 course in psoriasis patients.
- Identify factors linked to COVID-19 hospitalization.
Main Methods:
- International registry (Psoriasis Patient Registry for Outcomes, Therapy and Epidemiology of COVID-19 Infection) used.
- Clinician-reported cases of confirmed/suspected COVID-19 in psoriasis patients.
- Logistic regression analyzed hospitalization risk factors.
Main Results:
- Biologic therapy associated with lower hospitalization risk than nonbiologic therapy.
- Older age, male sex, nonwhite ethnicity, and lung disease increased hospitalization risk.
- No significant difference in hospitalization risk among biologic classes.
Conclusions:
- Biologic use linked to reduced COVID-19 hospitalization compared to nonbiologics.
- Traditional risk factors (age, sex, ethnicity, comorbidities) remain significant.
- Further research needed due to potential biases in observational data.
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