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Increased wiring cost during development is driven by long-range cortical, but not subcortical connections
Zilu Ma1, Wenyu Tu2, Nanyin Zhang3
1Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA 16802, United States.
Neuroimage
|October 19, 2020
Summary
Brain development shows uneven network costs, with increased wiring expenses in the cortex but decreased costs in subcortical connections as rats mature from juvenile to adult stages.
Area of Science:
- Neuroscience
- Developmental Neuroscience
- Computational Neuroscience
Background:
- The brain's maturation is a lengthy and energy-intensive process.
- Understanding how network costs are allocated during brain development is critical.
Purpose of the Study:
- To investigate developmental changes in brain network wiring cost and topology.
- To analyze how network resource distribution evolves from juvenile to adult stages.
Main Methods:
- Longitudinal resting-state functional magnetic resonance imaging (rsfMRI) in awake rats.
- Analysis of wiring cost and network topology during brain maturation.
Main Results:
- Wiring cost increased in most cortical connections but decreased in subcortico-subcortical connections.
- Developmental increase in wiring cost was primarily driven by long-range cortical connections.
- Cortical networks showed a more pronounced increase in network integration compared to subcortical networks.
Conclusions:
- Brain network cost distribution is non-uniform during maturation.
- Network resources are predominantly allocated to cortical development, not subcortical, from juvenile to adulthood.
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