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Updated: Dec 5, 2025
12:31
An Ex vivo Model to Study Hormone Action in the Human Breast
Published on: January 8, 2015
11.8K
Associations between Pregnane X Receptor and Breast Cancer Growth and Progression
Bradley A Creamer1, Shelly N B Sloan1, Jennifer F Dennis1
1Division of Basic Sciences, College of Osteopathic Medicine, Farber-McIntire Campus, Kansas City University, Joplin, MO 64804, USA.
Cells
|October 20, 2020
Summary
Pregnane X receptor (PXR) is implicated in breast cancer development. PXR influences cell proliferation, apoptosis, and drug resistance, suggesting its role in mammary tumor growth and progression.
Area of Science:
- Molecular Biology
- Oncology
- Pharmacology
Background:
- Pregnane X receptor (PXR) is a nuclear receptor involved in detoxification.
- PXR responds to a wide range of endogenous and exogenous compounds.
- PXR has known roles in the liver and gastrointestinal tract.
Purpose of the Study:
- To review the current understanding of PXR's function in breast cancer.
- To explore the link between PXR expression and mammary tumor development.
- To discuss PXR's influence on cancer cell biology.
Main Methods:
- Literature review of PXR's role in mammary carcinogenesis.
- Analysis of PXR expression in cancerous breast tissue.
- Examination of PXR's effects on cell cycle, apoptosis, and drug resistance.
Main Results:
- Elevated PXR expression is observed in breast cancer tissue.
- PXR promotes cell cycle progression, contributing to proliferation.
- PXR activation affects apoptosis and chemoresistance in cancer cells.
Conclusions:
- PXR plays a significant role in mammary tumor development and progression.
- PXR's influence on inflammation and genetic variations may increase breast cancer risk.
- Further research is needed to fully elucidate PXR's oncogenic functions.
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