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Pancreatitis Associated with Viral Hepatitis: Systematic Review
Nikola Panic1,2,3, Sladjana Mihajlovic1, Miroslav Vujasinovic3
1Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
Journal of Clinical Medicine
|October 20, 2020
Summary
Viral hepatitis can cause pancreatitis, a severe condition impacting patient outcomes. Awareness is crucial for effective treatment and improved survival rates in these cases.
Area of Science:
- Hepatology
- Gastroenterology
- Infectious Diseases
Background:
- Viral hepatitis is a significant global health concern.
- Pancreatitis is a known complication of various infections.
- The association between viral hepatitis and pancreatitis requires further investigation.
Purpose of the Study:
- To systematically review and summarize existing data on pancreatitis associated with viral hepatitis.
- To analyze the characteristics, outcomes, and risk factors of patients with viral hepatitis-induced pancreatitis.
Main Methods:
- A comprehensive literature search was performed across major scientific databases (Medline, Scopus, ISI Web of Science).
- Studies reporting data on patients with pancreatitis and viral hepatitis were identified and included.
- Data extraction and analysis were conducted on 46 studies involving 73 patients.
Main Results:
- Hepatitis A virus (HAV) and hepatitis E virus (HEV) were the most common causative agents.
- Pancreatitis was severe in 32.88% of cases, with significant mortality (21.92%).
- Fulminant hepatitis, multiorgan dysfunction syndrome (MODS), and severe pancreatitis were associated with increased mortality.
Conclusions:
- Pancreatic involvement in viral hepatitis necessitates increased clinical awareness.
- Early recognition and management of pancreatitis in viral hepatitis can significantly impact patient outcomes.
- Further research is warranted to elucidate the mechanisms and optimize treatment strategies.
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