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The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance

George I Lambrou1,2, Kyriaki Hatziagapiou1, Apostolos Zaravinos3

  • 1Choremeio Research Laboratory, First Department of Pediatrics, National and Kapodistrian University of Athens, Thivon & Levadeias 8, 11527 Goudi, Athens, Greece.

International Journal of Molecular Sciences
|October 20, 2020
PubMed

Insights

Growth arrest-specific transcript 5 (GAS5) functions as a tumor suppressor in various cancers. Its upregulation enhances sensitivity to cancer therapies like chemotherapy and radiotherapy, highlighting its role in overcoming treatment resistance.

Area of Science:

  • Molecular biology
  • Oncology
  • Biochemistry

Background:

  • Growth arrest-specific transcript 5 (GAS5) is a long noncoding RNA involved in cellular regulation.
  • GAS5 plays a role in critical cellular processes such as proliferation, apoptosis, invasion, and metastasis.
  • Dysregulation of GAS5 is implicated in various human cancers.

Purpose of the Study:

  • To review the literature on GAS5 expression in diverse human cancers.
  • To investigate the interaction of GAS5 with microRNAs (miRNAs).
  • To evaluate the impact of GAS5 on therapy-induced resistance in malignancies.

Main Methods:

  • Literature review of studies on GAS5 expression and function in cancer.
  • Analysis of GAS5 interactions with miRNAs.
  • Assessment of GAS5's role in chemo- and radio-resistance.

Main Results:

  • GAS5 is generally recognized as a tumor suppressor across multiple cancer types.
  • Upregulation of GAS5 expression correlates with increased tumor cell sensitivity to chemotherapy and radiotherapy.
  • GAS5 significantly influences therapy-induced resistance in various cancers.

Conclusions:

  • GAS5 acts as a crucial tumor suppressor in human cancers.
  • GAS5 modulation can enhance the efficacy of cancer treatments.
  • GAS5 plays a significant, previously underappreciated role in overcoming therapy resistance.
Keywords:
GAS5invasionmalignancymetastasisproliferationtumor growth

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