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Updated: Dec 5, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

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Oncogenic and Tumor-Suppressive Functions of NOTCH Signaling in Glioma

Elena Parmigiani1, Verdon Taylor1, Claudio Giachino1

  • 1Department of Biomedicine, University of Basel, Mattenstrasse 28, 4058 Basel, Switzerland.

Cells
|October 20, 2020
PubMed

Insights

NOTCH signaling

Area of Science:

  • Oncology
  • Neuroscience
  • Molecular Biology

Background:

  • NOTCH signaling is vital for tissue homeostasis.
  • Its role in cancer is complex, acting as both an oncogene and tumor suppressor.
  • Gliomas are aggressive brain tumors where NOTCH's function is debated.

Purpose of the Study:

  • To review the context-dependent role of NOTCH signaling in tumorigenesis.
  • To focus on the specific role of NOTCH in glioma development and progression.
  • To reconcile conflicting evidence regarding NOTCH's function in gliomas.

Main Methods:

  • Literature review of existing research on NOTCH signaling in cancer.
  • Analysis of studies investigating NOTCH's role in glioma subtypes.
  • Discussion of recent findings and unresolved questions.

Main Results:

  • NOTCH signaling can promote or suppress tumor development depending on the context.
  • Historically viewed as an oncogene in glioma due to neural stem cell promotion.
  • NOTCH-inactivating mutations in some gliomas challenge its oncogenic role, suggesting context-specific functions.

Conclusions:

  • The role of NOTCH signaling in glioma is complex and context-dependent.
  • Recent findings necessitate a re-evaluation of NOTCH's function in different glioma subtypes.
  • Further research is needed to fully understand and potentially target NOTCH signaling in brain tumors.
Keywords:
ASCL1CSLNOTCH signalingRBPJbrain tumorglioblastomagliomaneural stem cellsoncogenetumor suppressor

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