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Updated: Dec 5, 2025

Establishment of a Human Multiple Myeloma Xenograft Model in the Chicken to Study Tumor Growth, Invasion and Angiogenesis
Published on: May 1, 2015
Epigenetic Aberrations in Multiple Myeloma
Cinzia Caprio1, Antonio Sacco1, Viviana Giustini1
1CREA Laboratory, Clinical Research Development and Phase I Unit, ASST Spedali Civili di Brescia, 25123 Brescia, BS, Italy.
Abstract:
Multiple myeloma (MM) is a plasma cell dyscrasia characterized by proliferation of clonal plasma cells within the bone marrow. Several advances in defining key processes responsible for MM pathogenesis and disease progression have been made; and dysregulation of epigenetics, including DNA methylation and histone modification, has emerged as a crucial regulator of MM pathogenesis. In the present review article, we will focus on the role of epigenetic modifications within the specific context of MM.
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