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Functional roles of non-coding RNAs regulated by thyroid hormones in liver cancer

Po-Shuan Huang1, Cheng-Chih Chang2, Chia-Siu Wang2

  • 1Department of Biochemistry, College of Medicine, Chang Gung University, Taoyuan, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Biomedical Journal
|October 20, 2020
PubMed

Insights

Thyroid hormones regulate non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), which are crucial in liver cancer development. Understanding these interactions offers new insights into liver cancer biology.

Area of Science:

  • Genomics
  • Molecular Biology
  • Oncology

Background:

  • Non-coding RNAs (ncRNAs), including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), are increasingly recognized for their roles in cancer.
  • Dysregulation of ncRNAs can influence key cancer processes such as proliferation, angiogenesis, apoptosis, and metastasis.
  • Thyroid hormones and their receptors (TRs) are vital for development and implicated in various diseases, including liver cancer.

Purpose of the Study:

  • To review the current research on how thyroid hormones modulate ncRNA expression and function.
  • To explore the impact of thyroid hormone-regulated ncRNAs on human liver cells and liver cancer.

Main Methods:

  • Literature review of studies investigating thyroid hormones, ncRNAs, and liver cancer.
  • Analysis of the mechanisms by which thyroid hormone receptors (TRs) influence ncRNA expression.
  • Synthesis of findings on the functional roles of ncRNAs in thyroid hormone-associated liver cell functions.

Main Results:

  • Thyroid hormones significantly impact the expression of various ncRNAs, including miRNAs and lncRNAs.
  • Aberrant expression of TR isoforms is linked to different tumor types and stages.
  • Thyroid hormone-modulated ncRNAs play roles in cell proliferation, angiogenesis, apoptosis, and metastasis in liver cells.

Conclusions:

  • Thyroid hormone-regulated ncRNAs are critical players in liver cancer biology.
  • Further research into these interactions may reveal novel therapeutic targets for liver cancer.
Keywords:
Hepatocellular carcinomaNon-coding RNAReceptorsThyroid

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