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A new potential risk factor for central serous chorioretinopathy: blood pressure variability

Mehmet Fatih Karadağ1

  • 1Department of Ophthalmology, The Dunya Eye Hospital, Gaziantep, Turkey. drmfkaradag@gmail.com.

Eye (London, England)
|October 20, 2020
PubMed

Insights

Increased blood pressure variability (BPV) is linked to central serous chorioretinopathy (CSCR). This study found higher 24-hour and daytime BPV in CSCR patients, suggesting BPV as a new risk factor.

Area of Science:

  • Ophthalmology
  • Cardiology
  • Physiology

Background:

  • The choroid's vascular nature makes it susceptible to hemodynamic changes.
  • Blood pressure variability (BPV) may contribute to choroidal dysfunction and central serous chorioretinopathy (CSCR) development.

Purpose of the Study:

  • To investigate short-term BPV over 24 hours in patients with acute CSCR compared to healthy controls.

Main Methods:

  • A cross-sectional comparative study involving 50 CSCR patients and 60 healthy controls.
  • 24-hour ambulatory blood pressure monitoring with measurements every 15 minutes (day) and 30 minutes (night).
  • Statistical analysis of mean variability index (VI), systolic blood pressure (SBP), and diastolic blood pressure (DBP) during different periods.

Main Results:

  • No significant differences in mean 24-hour, daytime, or night-time SBP and DBP between groups.
  • Significantly higher mean 24-hour and daytime VI for SBP and DBP in the CSCR patient group.
  • Multivariate logistic regression identified 24-hour and daytime VI as independent risk factors for CSCR.

Conclusions:

  • Patients with CSCR exhibit significantly higher 24-hour and daytime SBP and DBP variability compared to controls.
  • Elevated BPV may represent a novel risk factor for the pathogenesis of CSCR.
Abstract

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