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Related Experiment Videos

Acute pyelonephritis in pregnancy.

Y D Fan1, J G Pastorek, J M Miller

  • 1Department of Obstetrics and Gynecology, Louisiana State University Medical Center, New Orleans.

American Journal of Perinatology
|October 1, 1987
PubMed
Summary

Pregnancy-associated pyelonephritis did not increase risks for premature birth or low birthweight. However, increasing antibiotic resistance, particularly to cephalothin, suggests current treatments may be less effective.

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Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Pharmacology

Background:

  • Pyelonephritis during pregnancy is a significant concern.
  • Previous studies have linked urinary tract infections in pregnancy to adverse birth outcomes.
  • Antibiotic resistance patterns are evolving, impacting treatment efficacy.

Purpose of the Study:

  • To investigate the association between pyelonephritis in pregnancy and adverse birth outcomes like prematurity and low birthweight.
  • To determine the antibiotic susceptibility patterns of common uropathogens in pregnant women.
  • To evaluate the appropriateness of current antibiotic treatment guidelines.

Main Methods:

  • Retrospective analysis of 107 episodes of pyelonephritis in 103 pregnant women.

Related Experiment Videos

  • Comparison of prematurity and low birthweight rates with a control group.
  • Identification and antibiotic susceptibility testing of bacterial isolates from urine samples.

    • Main Results:

    • No significant difference in prematurity or low birthweight was observed between the pyelonephritis group and the control group.
    • Enterobacteriaceae were the most frequent isolates.
    • High resistance rates were found for E. coli against ampicillin (33%) and cephalothin (13%).
    • 11% of isolates showed resistance to cephalothin, questioning its initial use.

    Conclusions:

    • Treated pyelonephritis in pregnancy does not appear to increase the risk of prematurity or low birthweight in this population.
    • The rising resistance to cephalothin suggests that first-generation cephalosporins may no longer be appropriate as initial therapy for pyelonephritis in pregnancy.
    • Monitoring antibiotic resistance patterns is crucial for effective management of urinary tract infections during pregnancy.