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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
Published on: August 15, 2016
Technological evolution of cyclodextrins in the pharmaceutical field
Juliana Rincón-López1, Yara C Almanza-Arjona2, Alejandro P Riascos3
1Instituto de Investigaciones en Materiales, Universidad Nacional Autónoma de México, Circuito Exterior S/N, Ciudad Universitaria, 04510, Mexico City, Mexico.
Cyclodextrin (CD) pharmaceutical technologies are expanding, with growth in oral and ocular formulations. Patent analysis reveals emerging trends and opportunities in various drug delivery routes.
Area of Science:
- Pharmaceutical Technology
- Supramolecular Chemistry
- Materials Science
Background:
- Cyclodextrins (CDs) are versatile pharmaceutical excipients.
- CDs enhance drug solubility, stability, and taste-masking.
- Patent data provides insights into technological evolution.
Purpose of the Study:
- To analyze the evolution of global cyclodextrin-based pharmaceutical technologies.
- To identify key technological trends and research opportunities using patent data.
- To understand the impact of CDs on various drug formulation routes.
Main Methods:
- Utilized a 1998 patent dataset from Derwent Innovation Index.
- Employed text-mining techniques on patent semantic content.
- Analyzed technologies related to CD attributes: solubility, stability, taste-masking.
Main Results:
- Parenteral aqueous solutions dominate current CD technologies.
- Oral and ocular formulation development shows rapid growth.
- Emerging potential in nasal, pulmonary, topical, and transdermal routes.
Conclusions:
- CD pharmaceutical technologies continue to increase, with sustained future growth expected.
- Patent monitoring is crucial for identifying R&D and investment opportunities.
- Advancements in materials science and nanotechnology will shape future CD applications.
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