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Related Concept Videos

Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

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The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
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Connective Tissue Cell Types01:22

Connective Tissue Cell Types

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Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
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Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
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Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
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Vitamins01:30

Vitamins

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Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
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Skeleton and Calcium Homeostasis01:21

Skeleton and Calcium Homeostasis

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Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
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Mineral, Vitamin and Water Absorption01:27

Mineral, Vitamin and Water Absorption

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Electrolytes are essential minerals and ions primarily obtained from the diet and absorbed through the gastrointestinal tract. Most electrolytes are absorbed in the small intestine. While the absorption of iron and calcium primarily occurs in the duodenum, calcium is also absorbed in the jejunum and ileum. In these regions, passive diffusion contributes to its absorption alongside active transport mechanisms in the duodenum. These ions can exit the enterocytes through specialized active...
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A combination of three antioxidants decreases the impact of rural particulate pollution in Normal human keratinocytes.

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Vitamin D Update.

Mary S Matsui1

  • 1Teaneck, NJ USA.

Current Dermatology Reports
|October 20, 2020
PubMed
Summary
This summary is machine-generated.

Vitamin D impacts non-skeletal health, immunity, and cardiovascular disease. Emerging evidence suggests a role in COVID-19 outcomes, necessitating updated guidance for sufficient vitamin D intake.

Keywords:
OsteomalaciaPigmentationRicketsSunscreenUltraviolet lightVitamin D

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Area of Science:

  • Endocrinology
  • Immunology
  • Public Health

Background:

  • Vitamin D is crucial for bone health, but its influence extends to innate immunity, cardiovascular health, and asthma.
  • Rickets, once thought eradicated, is resurging globally, highlighting persistent public health challenges.
  • Current sun protection practices, including broad-spectrum sunscreens, do not appear to negatively impact vitamin D levels in healthy individuals.

Purpose of the Study:

  • To review current understanding of vitamin D's role in non-skeletal health.
  • To address the complexities in guiding patients toward adequate vitamin D levels.
  • To explore vitamin D's potential involvement in SARS-CoV-2 (COVID-19) related morbidity and mortality.

Main Methods:

  • This is a review article, synthesizing existing research and literature.
  • No new experimental data was generated; the study relies on published findings.
  • Analysis of current guidelines and emerging scientific evidence.

Main Results:

  • Vitamin D plays a role in immune function and may influence cardiovascular disease and asthma.
  • There is a global resurgence of rickets, indicating challenges in maintaining adequate vitamin D status.
  • Individualized recommendations for vitamin D intake, considering diet, supplements, and sun exposure, are being developed.

Conclusions:

  • Vitamin D's significance extends beyond skeletal health, impacting various physiological systems.
  • Optimizing vitamin D levels requires personalized strategies due to complex influencing factors.
  • Further research is needed to fully elucidate vitamin D's role in COVID-19 and other non-skeletal conditions.