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Does low intensity direct current affect open fracture wound healing?
Yoyos Dias Ismiarto1, Kemas Abdul Mutholib Luthfi1, Mahyudin Mahyudin1
1Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Padjadjaran, Indonesia.
Summary
Low-intensity direct current (LIDC) significantly accelerates wound healing by boosting growth factor levels and fibroblast activation. This electrical stimulation therapy shows promising results for open fracture wound repair.
Area of Science:
- Regenerative Medicine
- Biomedical Engineering
- Wound Healing Research
Background:
- Open fracture wounds present significant challenges in healing.
- Current treatments for complex wounds have limitations.
- Understanding molecular pathways is crucial for improving wound repair.
Purpose of the Study:
- To investigate the impact of low-intensity direct current (LIDC) on wound healing.
- To explore LIDC's effect on growth factor signaling and fibroblast activation.
- To assess LIDC's efficacy in accelerating the repair of open fracture wounds.
Main Methods:
- A randomized clinical trial involving 32 patients with open fracture wounds.
- Comparison between a treatment group receiving LIDC and a control group.
- Evaluation of wound contraction, fibroblast growth factor (FGF2 and FGF7) levels, and fibroblast expression.
Main Results:
- The LIDC treatment group demonstrated superior wound area repair compared to the control group.
- Significant increases in FGF-2 and FGF-7 levels were observed in the LIDC group.
- Higher fibroblast group expression was noted in patients treated with LIDC (p < 0.05).
Conclusions:
- Low-intensity direct current effectively accelerates wound healing.
- LIDC enhances wound repair by upregulating growth factor production.
- Fibroblast activation is a key mechanism through which LIDC promotes healing.
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