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Updated: Dec 5, 2025

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

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Published on: November 9, 2019

Sequential and direct multicomponent reaction (MCR)-based dearomatization strategies.

Upendra K Sharma¹, Prabhat Ranjan, Erik V Van der Eycken

¹Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, B-3001, Leuven, Belgium. upendrakumar.sharma@kuleuven.be erik.vandereycken@kuleuven.be.

Chemical Society Reviews

|October 20, 2020

Summary

This summary is machine-generated.

Multicomponent reactions (MCRs) combined with dearomatization efficiently create complex, diverse heterocyclic compounds. This review explores these cascades for applications in asymmetric catalysis and medicinal chemistry.

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Area of Science:

Organic Chemistry
Synthetic Chemistry
Medicinal Chemistry

Background:

Dearomatization strategies are crucial for synthesizing complex heterocyclic frameworks.
Multicomponent reactions (MCRs) offer efficient routes to molecular complexity and diversity.
Natural product-like structures are often generated, attracting significant chemical interest.

Purpose of the Study:

To provide a systematic review of MCR cascades featuring dearomatization.
To offer a conceptual overview and comprehensive understanding of these synthetic strategies.
To highlight opportunities in drug discovery and novel scaffold development.

Main Methods:

Review of literature on dearomatization in multicomponent reactions.
Analysis of reaction cascades involving dearomatization as a key step.
Conceptual organization of MCR strategies for heterocyclic synthesis.

Main Results:

Dearomatization combined with MCRs enables the construction of intricate molecular architectures.
High atom economy and molecular diversity are achieved from simple precursors.
The review consolidates diverse MCR approaches for accessing complex heterocycles.

Conclusions:

Dearomatization-involved MCRs are powerful tools for generating molecular complexity and diversity.
These strategies hold significant potential for asymmetric catalysis and medicinal chemistry.
The review provides insights for future research in drug discovery and synthetic methodology.