Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lipid intermolecular hydrogen bonding: influence on structural organization and membrane function.

J M Boggs1

  • 1Department of Biochemistry, Hospital for Sick Children, Toronto, Canada.

Biochimica Et Biophysica Acta
|October 5, 1987
PubMed
Summary

Lipids interact via hydrogen bonds, influencing membrane physical properties like phase transition temperature and packing density. These interactions are crucial for lipid self-association and membrane organization, even in the presence of water.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated symptom and treatment side effect monitoring for improved quality of life among adults with diabetic peripheral neuropathy in primary care: a pragmatic, cluster, randomized, controlled trial.

Diabetic medicine : a journal of the British Diabetic Association·2018
Same author

A high-yield saponification of galactosylceramide I(3)-sulfate.

Lipids·2016
Same author

17β-Estradiol and 17α-estradiol induce rapid changes in cytoskeletal organization in cultured oligodendrocytes.

Neuroscience·2013
Same author

Critical and off-critical miscibility transitions in model extracellular and cytoplasmic myelin lipid monolayers.

Biophysical journal·2011
Same author

Interdigitation of Fatty Acid chains of dipalmitoylphosphatidylglycerol due to intercalation of myelin basic protein.

Biophysical journal·2009
Same author

Myelin basic protein: a multifunctional protein.

Cellular and molecular life sciences : CMLS·2006

Area of Science:

  • Biochemistry
  • Membrane Biophysics
  • Physical Chemistry

Background:

  • Lipid diversity suggests varied roles in membrane structure and function.
  • Acidic lipid groups are vital for protein and cation interactions.
  • Intermolecular hydrogen bonding between lipids is a key property influencing membrane behavior.

Purpose of the Study:

  • To explore the capacity of different lipid classes to engage in intermolecular hydrogen bonding.
  • To identify the specific molecular groups involved in lipid-hydrogen bonding.
  • To elucidate the impact of these hydrogen bonds on lipid physical properties.

Main Methods:

  • Analysis of lipid molecular structures and their potential for hydrogen bonding.
  • Correlation of observed lipid properties with molecular structures.

Related Experiment Videos

  • Review of existing literature on lipid-lipid and lipid-water interactions.

    • Main Results:

    • Intermolecular hydrogen bonding increases lipid phase transition temperature (8-30°C) and packing density.
    • Hydrogen bonding decreases lipid hydration and can slow lipid diffusion.
    • These interactions are stabilized by hydrophobic effects and Van der Waals forces, even in aqueous environments.

    Conclusions:

    • Lipid intermolecular hydrogen bonding significantly affects membrane physical properties.
    • Hydrogen bonding explains lipid self-association, asymmetric distribution, and interactions with cholesterol.
    • These interactions are critical for understanding lipid behavior in biological membranes.