Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Dec 5, 2025

Transcriptome Analysis of Single Cells
07:27

Transcriptome Analysis of Single Cells

Published on: April 25, 2011

30.4K

Cell populations in neonatal rat peripheral nerves identified by single-cell transcriptomics.

Ruirui Zhang1, Sailing Chen1, Xinghui Wang1

  • 1Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu, China.

Glia
|October 20, 2020
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Circular Bivalent Aptamer Chimeras Leveraging LDLR-Mediated Lysosomal Shuttling for Targeted Protein Degradation.

Journal of medicinal chemistry·2026
Same author

Physical activity behavior pathway from intention to action in older adults: a structural equation model based on the multi-process action control framework.

Frontiers in psychology·2026
Same author

Dual-targeting LILRB3/LILRB4 CAR-T cells for the treatment of monocytic acute myeloid leukemia.

Biochemical pharmacology·2026
Same author

Ultrasound-, CT-, and MRI-based logistic regression models for the diagnosis of supraclavicular lymph node metastasis in esophageal squamous cell carcinoma.

European journal of radiology·2026
Same author

The pivotal regulatory factor circ_0006956 promotes arsenic-induced lung carcinogenesis by enhancing the Warburg effect.

Chemico-biological interactions·2026
Same author

A Wash-Free Fluorescent Probe with Synergistic Signal Amplification for Sperm Microenvironment Evaluation and Asthenospermia Detection.

Analytical chemistry·2026

This study reveals the cellular diversity within neonatal rat peripheral nerves using single-cell sequencing. It identifies four distinct Schwann cell subtypes, highlighting their heterogeneity in the peripheral nervous system.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Genomics

Background:

  • Peripheral nerves are crucial for signal transduction, comprising various cell types.
  • The heterogeneity of cells, particularly Schwann cells, in peripheral nerves remains underexplored.

Purpose of the Study:

  • To comprehensively classify cell populations in neonatal rat sciatic nerves (SN) and dorsal root ganglia (DRG).
  • To investigate the heterogeneity of Schwann cells within the peripheral nervous system.

Main Methods:

  • High-coverage single-cell RNA sequencing was employed on neonatal rat SN and DRG.
  • Transcriptome-based cell typing identified 10 distinct cell populations.
  • Ligand-receptor interaction analysis explored cell-cell communications.
Keywords:
Schwann cellsdorsal root ganglianeonatal peripheral nervessciatic nervessingle-cell sequencing

More Related Videos

Single-cell Profiling of Developing and Mature Retinal Neurons
10:20

Single-cell Profiling of Developing and Mature Retinal Neurons

Published on: April 19, 2012

14.5K
Single-cell RNA-Seq of Defined Subsets of Retinal Ganglion Cells
11:26

Single-cell RNA-Seq of Defined Subsets of Retinal Ganglion Cells

Published on: May 22, 2017

14.2K

Related Experiment Videos

Last Updated: Dec 5, 2025

Transcriptome Analysis of Single Cells
07:27

Transcriptome Analysis of Single Cells

Published on: April 25, 2011

30.4K
Single-cell Profiling of Developing and Mature Retinal Neurons
10:20

Single-cell Profiling of Developing and Mature Retinal Neurons

Published on: April 19, 2012

14.5K
Single-cell RNA-Seq of Defined Subsets of Retinal Ganglion Cells
11:26

Single-cell RNA-Seq of Defined Subsets of Retinal Ganglion Cells

Published on: May 22, 2017

14.2K

Main Results:

  • Ten cell types were identified, including endothelial cells, fibroblasts, neurons, and Schwann cells.
  • Distinct cellular atlases were observed between SN and DRG.
  • Four novel Schwann cell subtypes with unique genetic markers and functions were discovered.

Conclusions:

  • Neonatal peripheral nerves exhibit significant cellular diversity and complexity.
  • Schwann cell heterogeneity is a key feature of the developing peripheral nervous system.