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Related Concept Videos

CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

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The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
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CRISPR01:59

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Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
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Plant Breeding and Biotechnology01:59

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Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.
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Transgenic Plants02:50

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Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
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Updated: Dec 5, 2025

Embryo Microinjection and Knockout Mutant Identification of CRISPR/Cas9 Genome-Edited Helicoverpa Armigera Hübner
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Engineering disease resistant plants through CRISPR-Cas9 technology.

Swati Tyagi1, Robin Kumar2,3, Vivak Kumar3

  • 1Genomic Division, National Institute of Agriculture Science, Rural Development Administration , Jeonju, Republic of Korea.

GM Crops & Food
|October 20, 2020
PubMed
Summary
This summary is machine-generated.

Plants face significant threats from pathogens, but CRISPR-Cas9 gene editing offers a powerful tool to enhance their natural immune systems, leading to improved disease resistance and food security.

Keywords:
CRISPR-Cas9Gene editingbiotic stressdisease Resistanceplant immune systemsusceptible genes

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Area of Science:

  • Plant Pathology
  • Molecular Biology
  • Biotechnology

Background:

  • Plants possess sophisticated immune systems, including PAMP-triggered immunity (PTI) and Effector-triggered immunity (ETI), to defend against bacterial, fungal, and viral pathogens.
  • Phytopathogens cause substantial pre- and post-harvest losses, impacting global food safety and agricultural economies.
  • Advancements in high-throughput molecular techniques facilitate the development of novel strategies for creating pathogen-resistant plants.

Purpose of the Study:

  • To review the complexities of the plant immune system.
  • To explore the application of CRISPR-Cas9 gene editing in modifying plant immune components for enhanced pathogen resistance.
  • To discuss the limitations, regulatory aspects, and future prospects of CRISPR-Cas9 technology in agriculture.

Main Methods:

  • Review of existing literature on plant immunity and CRISPR-Cas9 gene editing applications.
  • Analysis of molecular interactions between plants and phytopathogens.
  • Synthesis of information on CRISPR-Cas9-mediated trait alteration in plants.

Main Results:

  • CRISPR-Cas9 technology offers precise genome editing capabilities to enhance plant immune responses.
  • Editing key components of the plant immune system can confer durable resistance against a broad spectrum of phytopathogens.
  • The review highlights successful applications and potential of CRISPR-Cas9 in developing disease-resistant crops.

Conclusions:

  • CRISPR-Cas9-mediated enhancement of plant immunity presents a promising avenue for sustainable agriculture and food security.
  • Further research is needed to address the limitations and regulatory challenges associated with CRISPR-Cas9 edited crops.
  • The technology holds significant potential for future crop improvement and disease management strategies.