HD-eXplosion: visualization of hydrogen-deuterium exchange data as chiclet and volcano plots with statistical
Naifu Zhang1, Xiaohe Yu, Xinchao Zhang
1Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080, USA.
Summary:
Hydrogen-Deuterium eXchange coupled to mass spectrometry is a powerful tool for the analysis of protein dynamics and interactions. Bottom-up experiments looking at deuterium uptake differences between various conditions are the most common. These produce multi-dimensional data that can be challenging to depict in a single visual format. Each user must also set significance thresholds to define meaningful differences and make these apparent in data presentation. To assist in this process, we have created HD-eXplosion, an open-source, web-based application for the generation of chiclet and volcano plots with statistical filters. HD-eXplosion fills a void in available software packages and produces customizable plots that are publication quality.
Availability And Implementation:
The HD-eXplosion application is available at http://hd-explosion.utdallas.edu. The source code can be found at https://github.com/HD-Explosion.
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