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Updated: Dec 5, 2025

Large Volume, Behaviorally-relevant Illumination for Optogenetics in Non-human Primates
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An Open Resource for Non-human Primate Optogenetics.

Sébastien Tremblay1, Leah Acker2, Arash Afraz3

  • 1Department of Neuroscience, University of Pennsylvania, Philadelphia, PA 19104, USA.

Neuron
|October 20, 2020
PubMed

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Summary
This summary is machine-generated.

A new database centralizes optogenetics experiments in non-human primates (NHPs), aiding researchers. This open-science resource compiles over 1,000 injection experiments, including unpublished data, to improve future NHP optogenetics research.

Area of Science:

  • Neuroscience
  • Primate Research
  • Optogenetics

Background:

  • Optogenetics has transformed neuroscience in small animals but shows mixed results in non-human primates (NHPs).
  • A need exists for centralized data to guide evidence-based decisions in primate optogenetics.
  • Successful optogenetic studies in NHPs are crucial for advancing translational neuroscience.

Purpose of the Study:

  • To establish a centralized, open-access database of optogenetic experiments in NHPs.
  • To collect both successful and unsuccessful experimental outcomes to inform future research.
  • To provide insights and methodological considerations for improving optogenetics in primate models.

Main Methods:

  • Community outreach to 45 global laboratories for contributions to an open science initiative.
Keywords:
Gene therapyMonkeyMonkeysNon-human primatesNonhuman primatesOpen ScienceOptical controlOptogeneticOptogeneticsViral vectors

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  • Compilation of over 1,000 injection experiments with detailed methods and outcomes.
  • Data collection included previously unpublished experimental results.

    • Main Results:

    • The database contains over 1,000 NHP optogenetics injection experiments from 45 labs.
    • More than half of the contributed data represents previously unpublished experiments.
    • Initial insights from the database are reviewed, alongside methodological considerations.

    Conclusions:

    • The created database serves as a valuable, free resource for the scientific community.
    • Centralized data collection is essential for improving the success rate of optogenetics in NHPs.
    • Further contributions and analysis of the database will advance primate optogenetics research.