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Novel pathologic manifestation of idiopathic massive myocardial calcification

Kentaro Mitsui1, Takamichi Miyamoto1, Urara Sakurai2

  • 1Department of Cardiology, Japanese Red Cross Musashino Hospital, Musashino City, Tokyo, Japan.

Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology
|October 20, 2020
PubMed

Insights

Idiopathic myocardial calcification, a rare condition, can lead to progressive heart failure with preserved ejection fraction (HFpEF). This case highlights the worsening of calcification and diastolic dysfunction over time.

Area of Science:

  • Cardiology
  • Pathology

Background:

  • Idiopathic myocardial calcification is an exceptionally rare cardiac condition.
  • Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome.

Observation:

  • A 78-year-old woman presented with acute HFpEF.
  • Imaging revealed diffused calcified nodules within the myocardium.
  • Pathology confirmed myocardial calcified nodules and intramyocyte calcifications.

Findings:

  • The patient experienced progressive HFpEF, diastolic dysfunction, and worsening calcification.
  • Despite treatment for HFpEF, the condition advanced, leading to multiple hospitalizations.
  • Idiopathic myocardial calcification was identified as the underlying cause.

Implications:

  • Idiopathic myocardial calcification can be a direct cause of HFpEF.
  • The disease progression involves worsening calcification and diastolic dysfunction.
  • This case underscores the need for recognizing rare causes of heart failure.

Keywords:
AutopsyHeart failureIdiopathic myocardial calcificationMyocyteRare disease

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