Erchen decoction for hyperlipemia: Protocol for a systematic review and meta-analysis.

Area of Science:

• Metabolic disease research
• Cardiovascular health
• Traditional Chinese Medicine efficacy

Background:

• Hyperlipidemia is a key risk factor for atherosclerosis.
• Erchen decoction (ECD) is a common traditional Chinese medicine for hyperlipidemia in China.
• A systematic evaluation of ECD's efficacy and safety is needed.

Purpose of the Study:

• To systematically evaluate the efficacy and safety of Erchen decoction (ECD) for treating hyperlipidemia.
• To provide evidence-based data on ECD's effectiveness in managing lipid levels.
• To assess the safety profile of ECD in hyperlipidemia patients.

Main Methods:

• Systematic review and meta-analysis of randomized controlled trials (RCTs).
• Searched major Chinese and English databases up to September 30, 2020.
• Assessed efficacy using lipid profiles (LDL-C, TC, TG, HDL-C, ApoA, ApoB) and safety using liver enzymes, kidney function, and glucose levels.

Main Results:

• This study is expected to provide high-quality evidence on the effectiveness of ECD.
• The meta-analysis will quantify the impact of ECD on key lipid parameters.
• Safety data will be systematically analyzed to inform clinical use.

Conclusions:

• The findings will clarify the clinical effectiveness of Erchen decoction for hyperlipidemia.
• This review will guide the use of ECD in managing hyperlipidemia.
• Results will contribute to evidence-based practice in traditional Chinese medicine for metabolic disorders.