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Published on: January 28, 2020
Association of ANRIL polymorphisms with coronary artery disease: A systemic meta-analysis
Ya-Nan Zhang1, Bo Qiang2, Li-Juan Fu3
1Heilongjiang Provincial Hospital Affiliated to Harbin Institute of Technology.
Background:
The long noncoding RNAs have gradually been reported to be an important class of RNAs with pivotal roles in the development and progression of myocardial infarction (MI). In this study, we hypothesized that genetic variant of cyclin-dependent kinase inhibitor 2B antisense RNA (ANRIL) may affect the prognosis of MI patients.
Methods:
A systematic review and meta-analysis of studies including 11,269 cases and 10,707 controls on the association of 5 ANRIL single nucleotide polymorphism and the overall risk of MI or coronary artery disease (CAD) was performed.
Results:
In the meta-analysis, rs4977574 A > G, rs1333040 C > T, rs1333042 A > G and rs10757274 A > G ANRIL polymorphisms were correlated with overall MI or CAD risk. No significant associations were found between ANRIL rs1333049 G > C polymorphism and CAD risk.
Conclusions:
The results indicated that ANRIL polymorphism (rs4977574, rs1333040, rs1333042, and rs10757274) were more generally associated with CAD or MI risk. Further experimental studies to evaluate the limits of this hypothesis are warranted, and future functional studies are required to clarify the possible mechanisms.
Insights
Genetic variants in ANRIL, a long noncoding RNA, are linked to myocardial infarction (MI) and coronary artery disease (CAD) risk. Specific ANRIL polymorphisms show a significant association with increased risk for these cardiovascular conditions.
Area of Science:
- Genetics
- Cardiovascular Disease
- Molecular Biology
Background:
- Long noncoding RNAs (lncRNAs) play crucial roles in myocardial infarction (MI) development and progression.
- Genetic variations in ANRIL, a lncRNA, are investigated for their potential impact on MI patient prognosis.
Purpose of the Study:
- To investigate the association between ANRIL genetic variants and the risk of myocardial infarction (MI) or coronary artery disease (CAD).
Main Methods:
- A systematic review and meta-analysis was conducted.
- Included studies comprised 11,269 cases and 10,707 controls.
- Examined the association of five ANRIL single nucleotide polymorphisms (SNPs) with MI/CAD risk.
Main Results:
- Four ANRIL polymorphisms (rs4977574, rs1333040, rs1333042, and rs10757274) were significantly correlated with overall MI or CAD risk.
- No significant association was found for the ANRIL rs1333049 G>C polymorphism with CAD risk.
Conclusions:
- Specific ANRIL polymorphisms (rs4977574, rs1333040, rs1333042, and rs10757274) are generally associated with an increased risk of CAD or MI.
- Further experimental and functional studies are needed to elucidate the mechanisms underlying these associations.
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