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A new disposable electrochemical sensor uses molecularly imprinted polymers (MIPs) for rapid drug detection. This inexpensive sensor offers high sensitivity and selectivity for therapeutic drug monitoring, aiding in preventing adverse effects.

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ceramic chipdisposable sensorelectrochemical sensormolecularly imprinted polymertherapeutic drug monitoring

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Area of Science:

  • Electrochemistry
  • Materials Science
  • Analytical Chemistry

Background:

  • Therapeutic drug monitoring (TDM) is crucial for optimizing drug efficacy and minimizing toxicity.
  • Existing TDM methods can be time-consuming, expensive, or require specialized laboratory equipment.
  • Development of rapid, cost-effective, and selective sensors for point-of-care drug analysis is needed.

Purpose of the Study:

  • To develop an inexpensive, disposable electrochemical sensor for detecting multiple therapeutic drugs.
  • To utilize molecularly imprinted polymers (MIPs) for enhanced drug recognition and sensor performance.
  • To evaluate the sensor's sensitivity, linearity, selectivity, and stability in complex biological matrices.

Main Methods:

  • Fabrication of a disposable electrochemical sensor by immobilizing MIPs on graphite particles.
  • Utilizing a three-electrode ceramic-based chip sensor with MIP-modified working electrodes.
  • Employing differential pulse voltammetry (DPV) for quantitative drug analysis within therapeutic concentration ranges.
  • Testing sensor performance in plasma and whole blood samples to assess selectivity and interference effects.

Main Results:

  • The MIP-based sensor demonstrated higher sensitivity and linearity compared to non-imprinted polymer sensors.
  • The sensor exhibited excellent selectivity for target drugs (vancomycin, meropenem, theophylline, phenobarbital) against structurally similar compounds.
  • DPV measurements were rapid, requiring less than 2 minutes per analysis.
  • Interference from species in whole blood had a negligible impact on sensor performance.

Conclusions:

  • The developed disposable MIP sensor is a promising tool for quick and straightforward therapeutic drug monitoring.
  • This sensor technology can help prevent adverse drug reactions caused by underdosing or overdosing.
  • The sensor's low cost, disposability, and ease of use make it suitable for point-of-care applications.