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Single-dose treatment of lower urinary tract infections with fosfomycin trometamol: preliminary experiences

R Arione1, P Fontana

  • 1Dept. A, Amedeo di Savoia Hospital, Turin, Italy.

Chemioterapia : International Journal of the Mediterranean Society of Chemotherapy
|August 1, 1987
PubMed

Insights

Single oral doses of fosfomycin trometamol effectively treat lower urinary tract infections (UTIs), showing a 77% cure rate. This antibiotic therapy demonstrated particular success in adult females with uncomplicated UTIs, with no reported side effects.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Urology

Background:

  • Lower urinary tract infections (UTIs) are common, prompting research into effective single-dose therapies.
  • Fosfomycin trometamol is a phosphonic acid derivative investigated for UTI treatment efficacy.

Purpose of the Study:

  • To evaluate the efficacy and safety of a single oral dose of fosfomycin trometamol for lower UTIs.
  • To determine cure rates in a general patient population and specifically in adult females with uncomplicated UTIs.

Main Methods:

  • A clinical trial involving 26 patients (5 males, 21 females) with lower UTIs.
  • Treatment administered as a single oral dose of 3g fosfomycin trometamol.
  • Patients were assessed for cure rates four weeks post-treatment.

Main Results:

  • An overall cure rate of 77% (20/26 patients) was achieved four weeks after treatment.
  • In adult females with uncomplicated UTIs, the cure rate was 89% (16/18 patients).
  • No adverse side effects were reported by any patients receiving fosfomycin trometamol.

Conclusions:

  • Single oral dose fosfomycin trometamol is an effective treatment for lower UTIs.
  • The therapy shows high efficacy in adult females with uncomplicated UTIs.
  • Fosfomycin trometamol is well-tolerated, with a favorable safety profile for UTI management.

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