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Following the Dynamics of Structural Variants in Experimentally Evolved Populations

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Mutation bias can shape adaptation in large asexual populations experiencing clonal interference.

Kevin Gomez¹, Jason Bertram^2,3, Joanna Masel⁴

¹Graduate Interdisciplinary Program in Applied Mathematics, University of Arizona, Tucson, AZ, USA.

Proceedings. Biological Sciences

|October 21, 2020

Summary

Mutation-biased adaptation is not rare, even with clonal interference. The rate of adaptation depends on mutation rate and selection, not just selection, influencing evolutionary outcomes.

Keywords:

developmental bias elasticity modern synthesis mutation-driven adaptation parallel adaptation standard evolutionary theory

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Area of Science:

Evolutionary biology
Population genetics

Background:

The extended evolutionary synthesis proposes development influences adaptive evolution.
This concept aligns with mutation-biased adaptation in population genetics.
Clonal interference is cited as a reason mutation-biased adaptation is rare.

Purpose of the Study:

Investigate mutation-biased adaptation under clonal interference.
Analyze the impact of mutation rate (U) and selection coefficient (s) on adaptation.
Examine the conditions under which mutation-biased adaptation occurs.

Main Methods:

Utilized asexual travelling wave models.
Simultaneously analyzed two adapting traits with differing U and s.
Modeled adaptation rates (v) in isolation and under competition.

Main Results:

Adaptation is primarily driven by the trait with the faster isolated adaptation rate (v).
The other trait may experience evolutionary stalling.
Empirical claims for mutation-biased adaptation often involve large differences in U compared to s.

Conclusions:

Mutation-biased adaptation can occur even with significant clonal interference.
The relative importance of mutation rate versus selection depends on the specific population genetics regime.
Selection coefficient (s) offers limited advantage over mutation rate (U) when adaptation rates are equal.